Translational Research on Neuropharmacology and Movement Disorders
Ji-Seon Seo et al. found that p11 is highly expressed in ependymal cells, and is significantly decreased in patients with MDD, and in two mouse models of depression induced by chronic stress. These results identify a new role and a key molecular determinant for ependymal cell-driven CSF flow in mood disorders.
Mantas et al. found that tyramine and TAAR1 may play a critical role in the behavioral, transcriptional, and neurochemical effects of monoamine oxidase inhibitors, providing insights into the mechanisms underlying the effects of this class of drugs.
A review article has been published in Molecular Psychiatry.
The review focuses on how GPCRs mediate antidepressant actions and discusses recent insights into how GPCRs regulate the pathophysiology of Major Depressive Disorder (MDD).
Researchers at Karolinska Institutet have identified a protein in the brain that is important both for the function of the mood-regulating substance serotonin and for the release of stress hormones, at least in mice. The findings, which are published in the journal Molecular Psychiatry, may have implications for the development of new drugs for depression and anxiety.