Translational Research on Neuropharmacology and Movement Disorders
A review article has been published in Molecular Psychiatry.
The review focuses on how GPCRs mediate antidepressant actions and discusses recent insights into how GPCRs regulate the pathophysiology of Major Depressive Disorder (MDD).
Researchers at Karolinska Institutet have identified a protein in the brain that is important both for the function of the mood-regulating substance serotonin and for the release of stress hormones, at least in mice. The findings, which are published in the journal Molecular Psychiatry, may have implications for the development of new drugs for depression and anxiety.